Silica Gel 60 Adsorbents MACHEREY NAGEL LC Column 0.015-0.04 mm 1kg

Description

Product Overview

The MACHEREY NAGEL Silica Gel 60 Adsorbents are a premium bulk packing material designed specifically for liquid chromatography (LC) column applications. Each kilogram of product contains high‑purity silica particles with a tightly controlled size distribution ranging from 0.015 to 0.04 mm, providing a consistent packing matrix that promotes uniform flow and minimizes channeling. The material features a well‑defined pore size of approximately 60 Å, which is optimal for a wide variety of small‑molecule and peptide separations, delivering sharp peaks and excellent resolution. Manufactured under strict quality‑controlled conditions, the silica is free from metallic contaminants and exhibits a low moisture content, ensuring stability and reproducibility across multiple runs. The product is supplied in a convenient 1 kg bulk bag, making it suitable for both routine laboratory use and larger scale method development projects. Its compatibility with a broad range of organic solvents and aqueous buffers further enhances its versatility for diverse chromatographic workflows.

Usage

These silica gel adsorbents are ideal for packing analytical and preparative LC columns, including conventional stainless‑steel, PEEK, and polymer‑based housings. Users typically suspend the silica in a suitable solvent, such as methanol or acetonitrile, to create a slurry that can be packed under pressure using standard column packing equipment. The fine particle size range enables the formation of densely packed beds that support high linear velocities while maintaining low back‑pressure, which is essential for fast method development and high‑throughput screening. The material performs exceptionally well in reversed‑phase, normal‑phase, and mixed‑mode chromatography, making it a flexible choice for a variety of analyte classes, from pharmaceuticals to natural products. In addition, the robust silica matrix tolerates repeated regeneration cycles, allowing columns to be cleaned and reused without loss of performance. Typical applications include purity testing, impurity profiling, and preparative isolation of target compounds in research and production environments.

Why Choose Us

Choosing MACHEREY NAGEL as your supplier means partnering with a globally recognized leader in chromatography media. Our silica gel is produced using a proprietary synthesis process that yields highly uniform particles and consistent pore architecture, which translates directly into reliable chromatographic performance. Each batch undergoes rigorous analytical testing, including particle size analysis, pore size distribution, and surface area measurement, to guarantee that the specifications meet or exceed industry standards. We also provide comprehensive technical support, offering guidance on column packing protocols, method optimization, and troubleshooting to help you achieve the best possible results. Our commitment to sustainability is reflected in the environmentally responsible manufacturing practices and recyclable packaging we employ. When you purchase this product, you benefit from a combination of scientific expertise, dependable supply chain logistics, and responsive customer service that together ensure your laboratory operations run smoothly and efficiently.

Key Features

• Uniform 0.015‑0.04 mm particle size for consistent column packing and low back‑pressure.
• 60 Å pore size delivers high resolution for a wide range of analytes.
• High‑purity silica free from metal contaminants ensures reproducible results.
• Compatible with multiple solvent systems and column hardware for versatile use.
• Dedicated technical support and after‑sales service to assist with method development.

FAQ

What particle size range should I use for analytical versus preparative columns?

For analytical columns, the finer end of the 0.015‑0.04 mm range provides tighter packing and sharper peaks, while preparative columns can benefit from the slightly larger particles to reduce back‑pressure and allow higher flow rates. Adjust the slurry concentration accordingly to achieve optimal bed density for each application.

Can the silica be reused after column regeneration?

Yes, the silica gel can be regenerated multiple times using standard cleaning protocols such as solvent flushing or mild acid/base washes. Because the material is chemically stable and low in moisture, its performance remains consistent after several regeneration cycles, making it cost‑effective for routine laboratory use.

Is this product compatible with high‑pH mobile phases?

The silica is formulated to tolerate a pH range up to approximately 9.5, which covers most high‑pH reversed‑phase applications. For extreme pH conditions, we recommend evaluating column stability during method development to ensure long‑term durability.

How does the pore size affect separation of large biomolecules?

The 60 Å pore size is well‑suited for small to medium‑sized molecules, providing sufficient surface area for interaction. For very large biomolecules such as proteins or antibodies, larger pore silica (e.g., 120 Å) may be preferable to reduce steric hindrance and improve mass transfer.

What support does MACHEREY NAGEL provide for method optimization?

Our technical team offers personalized assistance, including recommended packing procedures, solvent selection, and troubleshooting tips. We also provide application notes and reference methods that illustrate how to achieve optimal performance with our silica gel in various chromatographic modes.